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Generally, ROS are by-products of biological metabolism in healthy organisms, though at lower amounts, which activate different signaling pathways to promote survival, proliferation, or resistance to oxidative stress (15)

Finally, the structures of the selected targets were further checked for their reliability using the same procedure adopted by us in a previous work 45 , in order to select only those targets with the highest possible structural reliability for the following steps

Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)

As a result, we need to make improvements in nanomaterials design and synthesis by mastering more profound understandings about the mechanisms of ICD